Study First to Show Metabolic Effects of Antipsychotic Medications in Youths

A study is the first to use gold-standard methods to test the hypothesis that antipsychotic treatment in youths adversely increases body fat and decreases insulin sensitivity. All three antipsychotics tested - oral aripiprazole, olanzapine, and risperidone, which are common first line use medications for children with nonpsychotic behavior disorders - increased not only total body fat, but also visceral and subcutaneous abdominal fat, associated with long-term risk for cardiovascular disease, high blood pressure and type 2 diabetes.

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