Researchers Discover Gene That Controls Bone-to-Fat Ratio in Bone Marrow

UCLA researchers have found that the PGC-1α gene, previously known to control human metabolism, also controls the equilibrium of bone and fat in bone marrow and also how an adult stem cell expresses its final cell type. The findings could lead to a better understanding of the disruption of bone-to-fat ratio in bone marrow and its health consequences, and point to the gene as a therapeutic target in the treatment of osteoporosis and skeletal aging.

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