Undefeated 49ers host Commanders in Week 6 Monday night football

The San Francisco 49ers will host the Washington Commanders on Monday Night Football at Levi's Stadium in Santa Clara, California, with kickoff set for 8:15 p.m. ET. The matchup marks Week 6 of the NFL season, pitting the undefeated 49ers against a Commanders team that has started the season 1-3-1.

The 49ers enter the game with a 5-0 record, having secured a 32-29 victory over the defending champion Seattle Seahawks in the previous week. In contrast, the Commanders are seeking a bounce back following a 27-27 overtime tie against the New York Giants. Betting markets have the 49ers laying 7.5 points, with the total points line rising to 52.5.

Injury reports indicate significant absences for both squads. The 49ers will be without star edge rusher Nick Bosa and receiver Deebo Samuel. Wide receiver Mike Evans was designated for the matchup after being a non-participant in practice on Friday due to multiple injuries. Additional 49ers players dealing with injuries include Demarcus Robinson, De'Zhaun Stribling, Ricky Pearsall, and Christian Kirk. The Washington Commanders will be without top running back Jacory Croskey-Merritt, along with several other players.

The game features a personal subplot involving 49ers left tackle Trent Williams, who is facing the franchise where he spent the first 10 years of his NFL career. Williams, who was selected by Washington as the fourth overall pick in the 2010 draft, stated that he sometimes forgets he played in Washington. "Sometimes I forget that I even played there," Williams said. "I've spent almost as much time here as I did there." Williams appeared in 120 games with the Commanders and earned seven straight Pro Bowl selections from 2012 to 2018.